MGF

MGF refers to Mechano Growth Factor, a hormone that is produced in muscle tis sue of animals when the muscles are trained. It is a C-terminal. 24 amino acids peptide. This chemical is considered to be an isoform of IGF-1. This spliced variant shares the mature region with IGF-1 but has a different Edomain. The C-terminal sequence between these two chemicals shows a distinct variant that allows researchers to differentiate between the two bodies. The C-terminal peptide of the Mechano Growth Factor (MGF) is a crucial region for the alternative splicing of the peptide. The alternative splicing in the MGF is brought about by the shift in the reading frame in which a specific C-terminal sequence (E- domain) is encoded by exon 5 and the first part of the exon 6. Another interesting point in MGF is that, because of the Edomain it contains. MGF can act on muscles independently from the rest of the molecule. Formula

Category: Peptide hormones

Mechanism of action

MGF is associated with promoting healing in the muscles of animal subjects after they have been damaged, or after a mechanical overload. In a natural setting, the chemical can stimulate the stem and satellite cells in addition to the necessary anabolic processes to promote the growth of new tissue or muscle fibers by tissues that were not damaged. It is believed that MGF and IGF-1 are central to the regrowth of muscle and the primary anabolic mechanism used to create new tissue. MGF is derived from IGF-1 but its sequence differs from the systemic

IGF-1 produced by the liver. MGF is expressed by mechanically overloaded muscle and is involved in tissue repair and adaptation. It is expressed as a pulse following muscle damage and is apparently involved in the activation of muscle satellite (stem) cells. The C-terminal peptide MGF. was found to function independently from the rest of the molecule. At any rate. IGF-1 exists in multiple isoforms (tissue-specific proteins of functional and structural similarity). One isoform, which differs from the systemic or liver type, happens to be particularly sensitive to mechanical signals such as the gamut of exercise overload. MGF is a local splice variant of IGF-1 produced by dam aged or loaded skeletal muscle.

The physiological function of MGF was studied using an in vitro cell model. Unlike mature IGF-1. the distinct Edomain of MGF inhibits terminal differentiation whilst increasing myoblast proliferation. Blocking the IGF-1 receptor with a specific antibody indicated that the function of MGF Edomain is mediated via a different receptor. The most relevant rodent data has been shown that MGF is a very potent inducer of muscle growth when it’s introduced into the muscle via an intramuscular injection. In fact, in one study MGF caused a 20% increase in the weight of the injected muscle within 2 weeks. The local application is appropriate for treatment to certain injuries and prevention of such in the treated muscle. Further investigation elucidated that this was actually due to an increase in the size of the muscle fibers.

Adverse reactions

None side effect have been noted from the product itself, however temporary irritation (redness, itching or small lumps) at the injection site is always a possibility, especially if injected into fat. The MGF peptide alone has a marked ability to enhance satellite cell activation, proliferation and fusion for muscle repair and maintenance and could provide a new strategy to combat age related sarcopenia without the oncogenic side effects observed for IGF1.( Kandalla , Goldspink , Butler-Browne , Mouly).

Dosage

It is recommended the following:

Administration should not be given within 2 hours after training in order not to reduce natural IGF-1 production.
Administration should not be given within 2 hours before sleeping in order not to reduce natural growth hormone production.
After administering, adequate protein needs to be ingested for MGF to be effective in building new muscle.

Theoretically the more locations used to administer the MGF into the muscle, the more places for muscle growth and prevention or treatment of injuries. So if you intent to administrate in two different muscles, at three different areas of the muscle, two times per day for one week, you must make a protocol like the following:

If you want to administer 1400mcg of MGF into the chest and biceps muscles twice a day and 3 different areas of the muscle then you would need to divide the dose as follows: 1400mcg / 2 times per day = 700mcg per administration

700mcg per administration / 4 muscles (2 chest and 2 bicep muscles) = 180mcg per muscle approximately 180mcg per muscle / 3 different locations on each muscle = 60 meg per injection (3 units on Insulin Syringe).

Note: Although listed options for the intake, each case must be examined individually and to consider personal and training characteristics of each person as well as possible interactions if you take other medicines.

Storage

Shelf life

This product can be used not more than 3 years from the production date ( see box)
After reconstitution, may be stored for a maximum of 30 days in a refrigerator at 2°C – 8°C.
Store vials in an upright position.
Store in a refrigerator (2°C – 8°C). Keep in the outer carton in order to protect from light.
For one month can be stored at room temperature.

Dopping test

Athletes which are subject to doping tests and they use MGF should know that is included in the list of banned substances of WADA. The products of BALCO don’t have marking agents and this preparation can’t be detected by regular testing of the urine. In blood test its presence is also absolutely undetectable 12 hours after the intake. In sudden blood test MGF can be detected for about 6 hours after taking the preparation.

Quality Control