Growth Hormone Releasing Peptide-2 is a single, non-glycosylated oligopeptide chain containing 6 amino acids. GH-releasing peptides (GHRPs) are synthetic peptides that like GHRH act directly on pituitary somatotrophs to stimulate GH release. GHRP-2, an investigational drug, is one of the most potent members of the GHRP family. GHRP-2 is a sterile, non-pyrogenic, white lyophilized powder intended for subcutaneous or intramuscular injection, after reconstitution with sterile Water for Injection. Its chemical structure is: Formula

Clinical pharmacology
GHRP-2 has been widely studied for its helpfulness and action as a growth hormone secretagogue (GHS), meaning it stimulates the secretion of growth hormone. It is known to promote hunger and appetite by stimulating Ghrelin release. The best use of GHRP-2 is correcting the production of low level of growth hormone. GHRP-2 also brings about an excess weight gain in unusually lean individuals. Growth Hormone Releasing Peptide-2 (GHRP-2) works to substantially activate the pituitary gland. This causes an increase in the production of the endogenous growth hormone. Thus, this peptide works to enhance your body’s own hormone which in turn brings about functionality from the natural hormone of the body without any of the adverse effects associated with synthetic growth hormone use. GHRP-2 enhances HGH production via a two-fold mechanism of action, for instance, a) it causes an increase in growth hormone via amplification of the transduction pathway of the natural growth hormone releasing hormone signal, and b) it suppresses the actions of somatostatin, thus both these pathways brings about an increase in the level of endogenous growth hormone.
GHRP-2 and GRF Analogue Interactions
It is important to know that GHRP-2 does not relate to any Growth Hormone Releasing Hormones (GHRH) peptides such as Sermorelin and CJC-1295 because it acts on differentreceptors. However, greater results occurred when administered in conjunction with a Growth Hormone Releasing Hormone (GHRH) such as CJC- 1295 (with DAC). Naturally, theseGHRP-2 peptide receptors interact with a hormone called ghrelin. Growth hormone releasing peptide -2 is a commercially synthesized, non-natural super-analog of GHRP-6 which iscapable of potent stimulatory effect on growth hormone (GH) secretion with slight stimulator effect in PRL, ACTH and levels of cortisol (Arvat et al. 1997). It is also a synthetic agonist ofghrelin that is binding with the growth hormone (GH) secretagogue receptor. GHRP-2 has been shown to affect and induce growth hormone secretion. The response of natural physiologicsystem includes increase in levels of calcium ion influx along side with increased release of growth hormones in response to this peptide.
Comparing GHRP-2 and GHRP-6
GHRP-2 is a 2nd generation GHRP just behind GHRP-6. Compared to GHRP-6, GHRP-2 is considered to be much more superior in terms of growth hormone stimulation because overlonger periods of time it maintains maximum elevations in Growth Hormone. GHRP-2 has shown to increase IGF-1 levels (Insulinlike Growth Factor 1), and even greater results happenwhen used with Growth Hormone Releasing Hormone (GHRH). It has a short half-life with peak concentrations occur ring around 15 minutes but not longer than 60 minutes. The responseof natural physiologic system includes increase in levels of calcium ion influx alongside with increased release of growth hormones in response to the high-amplitude pulsation from theGHRP-2. GHRP-2 and other ghrelin analogues increase the number of somatotropes involved in the GH pulse by inhibiting somatostatin. GHRH increases the pulse amplitude perpituitary cell or somatotrope by other means. Unlike ghrelin, GHRP-2 is not lipogenic which means that it does not induce fat storage.
Although ghrelin plays a large role in hunger, GHRP-2 as an analog of ghrelin does not increase appetite significantly.
Adverse reactions
The hunger side effects tied to GHRP-2 should be duly noted Usage of this pep tide can also come with elevated levels of cortisol and prolactin, especially if users are dosing in the higherranges – over 200mcg/injection. Another common side effect is the feeling of lethargy and tiredness upon first using GHRP-2. Water retention, tingling, numbness and decreased insulinsensitivity have also been cataloged as effects of GHRP-2. The most common positive side effect that bodybuilders and athletes will find with GHRP-2 are. decreased body fat, increaselean body mass, improved sleep, increase in IGF-1 production, increase in bone density and increase in cellular repair. WhileGHRP-2 has good and bad side effects, its would also betaken in to consideration that compared to GHRP-6,GHRP-2 is actually the mildest GHRP next in line to Ipamorelin.
Instructions for reconstitution
The dosageis injected 2-4 times a day. A sufficient dosage could be up to 300- 500mcg. The injections are usually made subcutaneously in an abdominal area 30 minutes before or in1-1.5 after meal. The time between injections should be 3-4 hours (in order the body has the time to produce GH for further release). Do not consume food for between 15-30 minutesafter your dosage. Best time is around 20-25 minute mark. GH pulses should peak within about 10 minutes after dosage. Fats and Carbohydrates affect the pulse dramatically. Proteinhas no effect on pulse. However, you can have a pure protein source in your stomach at any time if choose to do so. GHRP-2 can be taken in higher dosages, if needed; however, it isstill unclear how effective these high doses are.
Note: Although listed options for the intake, each case must be examined individually and to consider personal and training characteristics of each person as well as possible interactionsif you take other medicines.
Doping test
Athletes which are subject to doping tests and they use GHRP-2 should know that is included in the list of banned substances of WADA. The products of BALCO don’t have markingagents and this preparation can’t be detected by regular testing of the urine. In blood test its presence is also absolutely undetectable 12 hours after the intake. In sudden blood testGHRP-2 can be detected for about 6 hours after taking the preparation. Unlike direct intake of HGH the rise of levels here is close to physiological and it’s not detectable in doping test.
Shelf life
• This product can be used not more than 3 years from the production date ( see box)
• After reconstitution, may be stored for a maximum of 30 days in a refrigerator at 2°C – 8°C.
• Store vials in an upright position.
• Store in a refrigerator (2°C – 8°C). Keep in the outer carton in order to protect from light.
• For one month can be stored at room temperature.
Authenticity verification
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