CJC-1295

CJC-1295 is a tetrasubstituted 30-amino acid peptide hormone, primarily functioning as a growth hormone releasing hormone (GHRH) analog. It has D-Ala, Gln, Ala, and Leu substitu-tions at positions 2, 8, 15, and 27 respectively. CJC-1925 is a sterile, non-pyrogenic, white lyophilized powder intended for subcutaneous or intramuscular injection, after reconstitution with sterile Water for Injection. Formula

Mechanism of Action
Basically CJC-1295 is a long acting growth hormone releasing hormone (GHRH) analog. GHRH, also known as growth hormone releasing factor or somatocrinin, which is produced by the accurate nucleus in the hypothalamus. It stimulates secretion of growth hormone from the pituitary gland and is released in a pulsatile manner to ultimately stimulate pulsatile release of growth hormone. The result is an increasing level of both HGH ( Human Growth Hormone) and IGF-1 ( Insulin-like Growth Factor).

One very important advantage of CJC-1925 is that because of its half life, which is between 10- 30 minutes, the user can control the levels of HGH and IGF-1. That means you can have high levels, when you think its best for the results.

The possible benefits of CJC-1295 are:
• Fat loss
• Muscle gain
• Increased strength
• Improved skin tone
• Better sleep
• More energy
• Stronger bones
• Connective tissues

Special mention should be made about CJC-1295 ability to promote slow wave sleep. Slow wave sleep is also known as deep sleep and is the portion of sleep responsible for the highest level of muscle growth and memory retention. SWS is decreased significantly in older adults and also with people who tend to exercise later in the evening.
Several studies refer to CJC-1295 action. The 2005 CJC-1295 Study on women who injected the peptide for 90 days (3 months) indicated several key benefits of the peptide such as: an increase in Growth Hormone (GH) and IGF-1 levels; reduction in fat mass (stomach fat) and an increase in athletic physical performance (such as walking and stair climbing) – all of which occurred 100% as a result of simply taking the peptide (they did not do any special physical training or dieting in conjunction with the injections).

A 2004 Study, in men, indicated similar findings after 3 months of CJC-1295 injections: a 200% increase (doubling) of both HGH and IGF-1 levels; an increase in fat free mass (muscle) as well as a reduction in abdominal fat; and an improvement of physical performance, measured by the time it took to walk 30 minutes and to ascend four flights of stairs. Once again these excellent results were achieved by the injections alone, no special diet and weight or cardio training were followed.

The conclusions one can reach is that:
• CJC-1295 (Modified GRF 1-29) is anti-aging as it’s a potent increaser of HGH and IGF-1 levels which decline with age
• Results don’t happen overnight and you should take the product for 3 months minimum
• The peptide is effective on its own (however results would be far superior with diet and exercise)
• The peptides improve athletic performance, fat loss (particularly stomach fat) and increase muscle mass

Pharmacodynamics
CJC-1295 Peptide is generally very well tolerated by most individuals when used at the recommended dosages of about 100mcg per injection.

The most common side effect noted is a head “rush” and throbbing of the temples which occurs about 10 minutes post injection and can last up to 20 minutes. The side effect is nothing to be concerned about and is simply caused by a release of GABA (gamma-amino butyric acid, one neurotransmitter) in the brain – a good sign the peptide is working to stimulate HGH release. Of all releasing (peptide) hormones and stimulating HGH, CJC-1295 does not raise cortisol and water retention. By this the usual side effects such as swelling of fingers and joints pain are not observed. There is low influence on blood sugar levels, making it one of the best for burning fats. Does not increase appetite, exactly the opposite – by stabilizing blood glucose levels helps to control it.

Dosage
Recommended dosage of CJC-1295 :
• 0.10mg once per day for anti-aging.
• Between 0.20-0.30 mg, divided in two or three doses per day for muscle gain, fat loss or sports performance
• directed via subcutaneous injections. Maximum Dose per injection: 0.10 mg
Amount to Inject: If you have used 10ml of water for mixing, then an 0.10mg dosage = 0.2ml.

Note: Although listed options for the intake, each case must be examined individually and to consider personal and training characteristics of each person as well as possible interactions if you take other medicines.

Doping test
Athletes which are subject to doping tests and they use CJC-1295 should know that is included in the list of banned substances of WADA. The products of BALCO don’t have marking agents and this preparation can’t be detected by regular testing of the urine. In blood test its presence is also absolutely undetectable 12 hours after the intake. In sudden blood test CJC-1295 can be detected for about 6 hours after taking the preparation. Unlike direct intake of HGH the rise of levels here is close to physiological and it’s not detectable in doping test.
For optimal results
• Pre-injection: The purpose of injection CJC-1295 is to have it trigger a release of HGH in the body. Since fat and insulin (released after eating carbohydrates) both diminish the re- lease of HGH you should refrain from consuming any high fat or high carbohydrate meals or beverages for at least 2 hours before your injection (assuming you are injecting CJC- 1295 on its own). If you are however combining it with GHRP-6 peptide, studies in animals have indicated that when these peptides were taken together just 1 hour after eating their ability to release HGH wasn’t diminished. Therefore if your schedule is not so flexible in regard to meal timings, you may wish to combine CJC-1295 with GHRP-6 peptide.

• Post-injection: 30 minutes post-injection is usually when GHRH stimulation of HGH release is complete, meaning it’s safe to consume food/beverages after this time without worrying that they will cause your injection to be less effective. Those looking to burn fat should wait as long as possible before eating and when you do, only eat high protein, low fat and low carbohydrate meals to allow HGH’s fat burning effects to last as long as possible.

Storage
Shelf life
• This product can be used not more than 3 years from the production date ( see box)
• After reconstitution, may be stored for a maximum of 30 days in a refrigerator at 2°C – 8°C.
• Store vials in an upright position.
• Store in a refrigerator (2°C – 8°C). Keep in the outer carton in order to protect from light.
• For one month can be stored at room temperature.